1aj0 Summary



The structure was published by Achari, A., Somers, D.O., Champness, J.N., Bryant, P.K., Rosemond, J., and Stammers, D.K., in 1997 in a paper entitled "Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of DIHYDROPTEROATE SYNTHASE. This molecule has the UniProt identifier P0AC13 (DHPS_ECOLI)search. The sample contained 282 residues which is 100% of the natural sequence. Out of 282 residues 282 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DIHYDROPTEROATE SYNTHASE P0AC13 (1-282) (DHPS_ECOLI)search Escherichia coli K-12search 100% 282 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0AC13 (1 - 282) DIHYDROPTEROATE SYNTHASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0AC13) Dihydropteroate synthetasesearch Dihydropteroate (DHP) synthetasesearch PF00809: Pterin binding enzymesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P0AC13) pteridine-containing compound metabolic processsearch cellular metabolic processsearch folic acid-containing compound biosynthetic processsearch tetrahydrofolate biosynthetic processsearch folic acid biosynthetic processsearch response to drugsearch response to antibioticsearch dihydropteroate synthase activitysearch metal ion bindingsearch transferase activitysearch cytoplasmsearch

Chain InterPro annotation
A Pterin-bindingsearch Dihydropteroate synthasesearch Dihydropteroate synthase-likesearch