› 1aiy

Solution NMR

R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1aiy/pdb
PDB entry 1aiy coloured by chain, ensemble of 10 models, front view.
PDB entry 1aiy coloured by chain, ensemble of 10 models, side view.
PDB entry 1aiy coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the R6 human insulin hexamer,.
Chang X, Jorgensen AM, Bardrum P, Led JJ
Biochemistry 36 9409-22 (1997)
PMID: 9235985

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand IPH 6 x IPH
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING AND ENERGY MINIMIZATION

Quick links

Citations

7 review citations

Insulin and its receptor: structure, function and evolution.
De Meyts P. (2004)
6 more

4 mentions without citation

Progress in Simulation Studies of Insulin Structure and Function.
Gorai et al. (2022)
3 more