1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P04083) calcium ion bindingsearch calcium-dependent phospholipid bindingsearch structural molecule activitysearch phospholipid bindingsearch receptor bindingsearch single-stranded DNA bindingsearch phospholipase inhibitor activitysearch annealing helicase activitysearch calcium-dependent protein bindingsearch phospholipase A2 inhibitor activitysearch helicase activitysearch protein binding, bridgingsearch protein bindingsearch protein homodimerization activitysearch double-stranded DNA-dependent ATPase activitysearch single-stranded RNA bindingsearch extracellular regionsearch extracellular spacesearch cell projectionsearch extracellular exosomesearch membranesearch focal adhesionsearch mitochondrial membranesearch cytoplasmsearch plasma membranesearch cell surfacesearch sarcolemmasearch ciliumsearch cornified envelopesearch endosomesearch mast cell granulesearch nucleussearch basolateral plasma membranesearch protein complexsearch vesiclesearch response to glucocorticoidsearch positive regulation of prostaglandin biosynthetic processsearch response to hormonesearch insulin secretionsearch positive regulation of neutrophil apoptotic processsearch neutrophil homeostasissearch response to drugsearch response to corticosteroidsearch cell surface receptor signaling pathwaysearch positive regulation of G1/S transition of mitotic cell cyclesearch DNA duplex unwindingsearch DNA strand renaturationsearch signal transductionsearch alpha-beta T cell differentiationsearch negative regulation of protein secretionsearch prostate gland developmentsearch endocrine pancreas developmentsearch cellular response to glucocorticoid stimulussearch movement of cell or subcellular componentsearch response to X-raysearch peptide cross-linkingsearch neutrophil clearancesearch negative regulation of phospholipase A2 activitysearch arachidonic acid secretionsearch response to estradiolsearch response to interleukin-1search hepatocyte differentiationsearch response to peptide hormonesearch DNA rewindingsearch response to organic cyclic compoundsearch inflammatory responsesearch positive regulation of apoptotic processsearch negative regulation of interleukin-8 secretionsearch gliogenesissearch keratinocyte differentiationsearch prolactin secretionsearch negative regulation of apoptotic processsearch cellular response to hydrogen peroxidesearch regulation of cell proliferationsearch positive regulation of vesicle fusionsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch