1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P04083) calcium ion bindingsearch protein homodimerization activitysearch protein bindingsearch calcium-dependent phospholipid bindingsearch phospholipase inhibitor activitysearch structural molecule activitysearch phospholipid bindingsearch phospholipase A2 inhibitor activitysearch receptor bindingsearch protein binding, bridgingsearch calcium-dependent protein bindingsearch extracellular spacesearch extracellular regionsearch extracellular vesicular exosomesearch cytoplasmsearch plasma membranesearch vesiclesearch mitochondrial membranesearch membranesearch nucleussearch ciliumsearch protein complexsearch focal adhesionsearch cell surfacesearch basolateral plasma membranesearch cornified envelopesearch cell projectionsearch endosomesearch sarcolemmasearch negative regulation of interleukin-8 secretionsearch keratinocyte differentiationsearch arachidonic acid secretionsearch inflammatory responsesearch positive regulation of prostaglandin biosynthetic processsearch negative regulation of apoptotic processsearch negative regulation of catalytic activitysearch positive regulation of vesicle fusionsearch alpha-beta T cell differentiationsearch hepatocyte differentiationsearch signal transductionsearch response to X-raysearch cellular response to glucocorticoid stimulussearch cellular response to hydrogen peroxidesearch response to organic cyclic compoundsearch regulation of cell proliferationsearch neutrophil homeostasissearch negative regulation of protein secretionsearch estrous cycle phasesearch response to interleukin-1search response to corticosteroidsearch response to hormonesearch positive regulation of neutrophil apoptotic processsearch insulin secretionsearch gliogenesissearch cell surface receptor signaling pathwaysearch negative regulation of acute inflammatory responsesearch peptide cross-linkingsearch neutrophil clearancesearch positive regulation of apoptotic processsearch response to glucocorticoidsearch cellular component movementsearch response to peptide hormonesearch positive regulation of G1/S transition of mitotic cell cyclesearch response to drugsearch response to estradiolsearch endocrine pancreas developmentsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch