1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P04083) extracellular spacesearch extracellular regionsearch extracellular vesicular exosomesearch plasma membranesearch cell surfacesearch focal adhesionsearch protein complexsearch nucleussearch cytoplasmsearch sarcolemmasearch basolateral plasma membranesearch ciliumsearch endosomesearch cornified envelopesearch mast cell granulesearch mitochondrial membranesearch membranesearch cell projectionsearch vesiclesearch gliogenesissearch ATP catabolic processsearch endocrine pancreas developmentsearch response to glucocorticoidsearch signal transductionsearch regulation of cell proliferationsearch negative regulation of phospholipase A2 activitysearch neutrophil homeostasissearch arachidonic acid secretionsearch response to drugsearch response to organic cyclic compoundsearch hepatocyte differentiationsearch insulin secretionsearch positive regulation of apoptotic processsearch peptide cross-linkingsearch neutrophil clearancesearch DNA rewindingsearch response to estradiolsearch response to interleukin-1search cell surface receptor signaling pathwaysearch response to X-raysearch DNA strand renaturationsearch prolactin secretionsearch cellular component movementsearch response to peptide hormonesearch positive regulation of G1/S transition of mitotic cell cyclesearch prostate gland developmentsearch DNA duplex unwindingsearch negative regulation of protein secretionsearch cellular response to hydrogen peroxidesearch alpha-beta T cell differentiationsearch response to corticosteroidsearch cellular response to glucocorticoid stimulussearch positive regulation of prostaglandin biosynthetic processsearch positive regulation of neutrophil apoptotic processsearch negative regulation of apoptotic processsearch positive regulation of vesicle fusionsearch negative regulation of interleukin-8 secretionsearch keratinocyte differentiationsearch response to hormonesearch inflammatory responsesearch structural molecule activitysearch phospholipid bindingsearch calcium ion bindingsearch protein homodimerization activitysearch single-stranded RNA bindingsearch double-stranded DNA-dependent ATPase activitysearch calcium-dependent phospholipid bindingsearch annealing helicase activitysearch receptor bindingsearch phospholipase inhibitor activitysearch calcium-dependent protein bindingsearch protein bindingsearch phospholipase A2 inhibitor activitysearch protein binding, bridgingsearch helicase activitysearch single-stranded DNA bindingsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch