1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04083) calcium-dependent phospholipid bindingsearch calcium-dependent protein bindingsearch protein bindingsearch phospholipid bindingsearch phospholipase A2 inhibitor activitysearch protein binding, bridgingsearch annealing helicase activitysearch calcium ion bindingsearch protein homodimerization activitysearch phospholipase inhibitor activitysearch single-stranded RNA bindingsearch structural molecule activitysearch helicase activitysearch receptor bindingsearch single-stranded DNA bindingsearch double-stranded DNA-dependent ATPase activitysearch signal transductionsearch movement of cell or subcellular componentsearch response to organic cyclic compoundsearch hepatocyte differentiationsearch DNA rewindingsearch peptide cross-linkingsearch neutrophil clearancesearch regulation of cell proliferationsearch response to interleukin-1search response to hormonesearch cellular response to glucocorticoid stimulussearch negative regulation of apoptotic processsearch positive regulation of vesicle fusionsearch alpha-beta T cell differentiationsearch response to drugsearch positive regulation of apoptotic processsearch negative regulation of interleukin-8 secretionsearch keratinocyte differentiationsearch response to peptide hormonesearch response to X-raysearch response to estradiolsearch response to glucocorticoidsearch cell surface receptor signaling pathwaysearch inflammatory responsesearch positive regulation of prostaglandin biosynthetic processsearch gliogenesissearch neutrophil homeostasissearch response to corticosteroidsearch negative regulation of protein secretionsearch arachidonic acid secretionsearch DNA duplex unwindingsearch cellular response to hydrogen peroxidesearch negative regulation of phospholipase A2 activitysearch prolactin secretionsearch prostate gland developmentsearch positive regulation of G1/S transition of mitotic cell cyclesearch endocrine pancreas developmentsearch DNA strand renaturationsearch positive regulation of neutrophil apoptotic processsearch insulin secretionsearch ATP catabolic processsearch extracellular vesicular exosomesearch cytoplasmsearch extracellular regionsearch endosomesearch mitochondrial membranesearch vesiclesearch nucleussearch extracellular spacesearch basolateral plasma membranesearch plasma membranesearch cell projectionsearch focal adhesionsearch mast cell granulesearch ciliumsearch sarcolemmasearch membranesearch cell surfacesearch protein complexsearch cornified envelopesearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch