1ain Summary

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CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION

The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04083) calcium-dependent phospholipid bindingsearch calcium ion bindingsearch phospholipase inhibitor activitysearch phospholipase A2 inhibitor activitysearch phospholipid bindingsearch protein bindingsearch structural molecule activitysearch protein homodimerization activitysearch protein binding, bridgingsearch receptor bindingsearch positive regulation of apoptotic processsearch response to corticosteroid stimulussearch negative regulation of apoptotic processsearch insulin secretionsearch alpha-beta T cell differentiationsearch regulation of cell proliferationsearch positive regulation of prostaglandin biosynthetic processsearch cell surface receptor signaling pathwaysearch signal transductionsearch inflammatory responsesearch response to organic cyclic compoundsearch response to estradiol stimulussearch response to X-raysearch positive regulation of neutrophil apoptotic processsearch neutrophil homeostasissearch response to peptide hormone stimulussearch arachidonic acid secretionsearch endocrine pancreas developmentsearch keratinocyte differentiationsearch neutrophil clearancesearch cell cyclesearch response to glucocorticoid stimulussearch hepatocyte differentiationsearch negative regulation of protein secretionsearch response to drugsearch cellular response to glucocorticoid stimulussearch cellular response to hydrogen peroxidesearch response to hormone stimulussearch estrous cycle phasesearch response to interleukin-1search peptide cross-linkingsearch positive regulation of vesicle fusionsearch cellular component movementsearch gliogenesissearch negative regulation of acute inflammatory responsesearch nucleussearch cytoplasmsearch protein complexsearch plasma membranesearch basolateral plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch cornified envelopesearch membranesearch mitochondrial membranesearch cell projectionsearch ciliumsearch extracellular regionsearch sarcolemmasearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch