1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P04083) extracellular regionsearch cell surfacesearch extracellular spacesearch protein complexsearch extracellular vesicular exosomesearch plasma membranesearch cell projectionsearch ciliumsearch basolateral plasma membranesearch focal adhesionsearch endosomesearch membranesearch cytoplasmsearch nucleussearch cornified envelopesearch mitochondrial membranesearch sarcolemmasearch mast cell granulesearch vesiclesearch annealing helicase activitysearch structural molecule activitysearch phospholipid bindingsearch double-stranded DNA-dependent ATPase activitysearch calcium ion bindingsearch calcium-dependent phospholipid bindingsearch protein bindingsearch phospholipase A2 inhibitor activitysearch single-stranded RNA bindingsearch helicase activitysearch receptor bindingsearch protein binding, bridgingsearch calcium-dependent protein bindingsearch protein homodimerization activitysearch single-stranded DNA bindingsearch phospholipase inhibitor activitysearch positive regulation of apoptotic processsearch prolactin secretionsearch response to peptide hormonesearch negative regulation of protein secretionsearch ATP catabolic processsearch prostate gland developmentsearch neutrophil homeostasissearch response to estradiolsearch peptide cross-linkingsearch neutrophil clearancesearch response to X-raysearch positive regulation of G1/S transition of mitotic cell cyclesearch DNA rewindingsearch insulin secretionsearch negative regulation of phospholipase A2 activitysearch gliogenesissearch cell surface receptor signaling pathwaysearch cellular response to hydrogen peroxidesearch positive regulation of neutrophil apoptotic processsearch signal transductionsearch response to glucocorticoidsearch response to drugsearch cellular response to glucocorticoid stimulussearch alpha-beta T cell differentiationsearch cellular component movementsearch DNA strand renaturationsearch regulation of cell proliferationsearch response to organic cyclic compoundsearch DNA duplex unwindingsearch keratinocyte differentiationsearch negative regulation of interleukin-8 secretionsearch response to corticosteroidsearch response to interleukin-1search hepatocyte differentiationsearch inflammatory responsesearch negative regulation of apoptotic processsearch positive regulation of vesicle fusionsearch endocrine pancreas developmentsearch arachidonic acid secretionsearch response to hormonesearch positive regulation of prostaglandin biosynthetic processsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch