1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04083) calcium-dependent phospholipid bindingsearch phospholipase inhibitor activitysearch calcium ion bindingsearch phospholipase A2 inhibitor activitysearch protein bindingsearch protein homodimerization activitysearch receptor bindingsearch phospholipid bindingsearch structural molecule activitysearch protein binding, bridgingsearch calcium-dependent protein bindingsearch negative regulation of catalytic activitysearch positive regulation of prostaglandin biosynthetic processsearch alpha-beta T cell differentiationsearch neutrophil homeostasissearch regulation of cell proliferationsearch response to estradiolsearch estrous cycle phasesearch cell surface receptor signaling pathwaysearch gliogenesissearch positive regulation of apoptotic processsearch response to X-raysearch response to glucocorticoidsearch endocrine pancreas developmentsearch cellular response to glucocorticoid stimulussearch response to corticosteroidsearch insulin secretionsearch negative regulation of protein secretionsearch response to organic cyclic compoundsearch response to interleukin-1search negative regulation of acute inflammatory responsesearch response to drugsearch hepatocyte differentiationsearch signal transductionsearch cellular component movementsearch positive regulation of G1/S transition of mitotic cell cyclesearch response to peptide hormonesearch peptide cross-linkingsearch neutrophil clearancesearch arachidonic acid secretionsearch positive regulation of vesicle fusionsearch cellular response to hydrogen peroxidesearch inflammatory responsesearch negative regulation of apoptotic processsearch keratinocyte differentiationsearch positive regulation of neutrophil apoptotic processsearch response to hormonesearch negative regulation of interleukin-8 secretionsearch extracellular spacesearch extracellular regionsearch extracellular vesicular exosomesearch membranesearch nucleussearch cytoplasmsearch cornified envelopesearch sarcolemmasearch ciliumsearch plasma membranesearch cell surfacesearch mitochondrial membranesearch basolateral plasma membranesearch cell projectionsearch protein complexsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch