1ain Summary



The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P04083) extracellular spacesearch nucleussearch extracellular regionsearch plasma membranesearch extracellular vesicular exosomesearch focal adhesionsearch cell surfacesearch ciliumsearch cytoplasmsearch membranesearch cornified envelopesearch endosomesearch protein complexsearch mitochondrial membranesearch sarcolemmasearch vesiclesearch cell projectionsearch alpha-beta T cell differentiationsearch negative regulation of catalytic activitysearch response to interleukin-1search neutrophil homeostasissearch positive regulation of prostaglandin biosynthetic processsearch regulation of cell proliferationsearch positive regulation of neutrophil apoptotic processsearch negative regulation of apoptotic processsearch response to X-raysearch hepatocyte differentiationsearch cell surface receptor signaling pathwaysearch response to drugsearch signal transductionsearch peptide cross-linkingsearch neutrophil clearancesearch positive regulation of apoptotic processsearch response to estradiolsearch negative regulation of acute inflammatory responsesearch gliogenesissearch cellular component movementsearch insulin secretionsearch positive regulation of G1/S transition of mitotic cell cyclesearch response to organic cyclic compoundsearch keratinocyte differentiationsearch response to glucocorticoidsearch endocrine pancreas developmentsearch arachidonic acid secretionsearch negative regulation of interleukin-8 secretionsearch response to peptide hormonesearch negative regulation of protein secretionsearch response to hormonesearch cellular response to glucocorticoid stimulussearch response to corticosteroidsearch cellular response to hydrogen peroxidesearch positive regulation of vesicle fusionsearch inflammatory responsesearch phospholipase A2 inhibitor activitysearch calcium ion bindingsearch structural molecule activitysearch phospholipid bindingsearch protein bindingsearch calcium-dependent phospholipid bindingsearch receptor bindingsearch calcium-dependent protein bindingsearch protein binding, bridgingsearch protein homodimerization activitysearch phospholipase inhibitor activitysearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch