1ain Summary

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CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION

The structure was published by Weng, X., Luecke, H., Song, I.S., Kang, D.S., Kim, S.H., and Huber, R., in 1993 in a paper entitled "Crystal structure of human annexin I at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ANNEXIN I. This molecule has the UniProt identifier P04083 (ANXA1_HUMAN)search. The sample contained 314 residues which is 91% of the natural sequence. Out of 314 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ANNEXIN I P04083 (33-346) (ANXA1_HUMAN)search Homo sapienssearch 91% 314 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04083 (33 - 346) ANNEXIN I Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P04083) Annexinsearch PF00191: Annexinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P04083) DNA strand renaturationsearch neutrophil homeostasissearch movement of cell or subcellular componentsearch inflammatory responsesearch signal transductionsearch cell surface receptor signaling pathwaysearch response to hormonesearch response to X-raysearch response to organic cyclic compoundsearch peptide cross-linkingsearch insulin secretionsearch keratinocyte differentiationsearch prostate gland developmentsearch endocrine pancreas developmentsearch positive regulation of vesicle fusionsearch positive regulation of prostaglandin biosynthetic processsearch response to corticosteroidsearch response to estradiolsearch DNA duplex unwindingsearch positive regulation of neutrophil apoptotic processsearch DNA rewindingsearch gliogenesissearch regulation of cell proliferationsearch response to drugsearch positive regulation of apoptotic processsearch negative regulation of apoptotic processsearch response to peptide hormonesearch alpha-beta T cell differentiationsearch arachidonic acid secretionsearch negative regulation of protein secretionsearch response to glucocorticoidsearch cellular response to hydrogen peroxidesearch hepatocyte differentiationsearch prolactin secretionsearch response to interleukin-1search cellular response to glucocorticoid stimulussearch neutrophil clearancesearch positive regulation of G1/S transition of mitotic cell cyclesearch negative regulation of phospholipase A2 activitysearch negative regulation of interleukin-8 secretionsearch cornified envelopesearch extracellular regionsearch extracellular spacesearch nucleussearch cytoplasmsearch endosomesearch plasma membranesearch focal adhesionsearch ciliumsearch cell surfacesearch membranesearch basolateral plasma membranesearch mitochondrial membranesearch vesiclesearch sarcolemmasearch mast cell granulesearch cell projectionsearch protein complexsearch extracellular vesicular exosomesearch single-stranded DNA bindingsearch single-stranded RNA bindingsearch helicase activitysearch phospholipase inhibitor activitysearch receptor bindingsearch structural molecule activitysearch calcium ion bindingsearch protein bindingsearch phospholipid bindingsearch calcium-dependent phospholipid bindingsearch phospholipase A2 inhibitor activitysearch protein binding, bridgingsearch double-stranded DNA-dependent ATPase activitysearch annealing helicase activitysearch protein homodimerization activitysearch calcium-dependent protein bindingsearch

Chain InterPro annotation
A Annexinsearch Annexin, type Isearch Annexin repeat, conserved sitesearch Annexin repeatsearch