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R6 HUMAN INSULIN HEXAMER (NON-SYMMETRIC), NMR, 10 STRUCTURES

Solution NMR
PDB entry 1ai0 coloured by chain, ensemble of 10 models, front view.
PDB entry 1ai0 coloured by chain, ensemble of 10 models, side view.
PDB entry 1ai0 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 17651.06 Å2
Buried surface area: 16597.36 Å2
Dissociation area: 3,445.65 Å2
Dissociation energy (ΔGdiss): 4.62 kcal/mol
Dissociation entropy (TΔSdiss): 12.8 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1ai0, assembly 1, front view.
Insulin A chain in PDB entry 1ai0, assembly 1, side view.
Insulin A chain in PDB entry 1ai0, assembly 1, top view.
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Insulin B chain
Chains: B, D, F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1ai0, assembly 1, front view.
Insulin B chain in PDB entry 1ai0, assembly 1, side view.
Insulin B chain in PDB entry 1ai0, assembly 1, top view.
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