1aht Summary

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CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION

The structure was published by Chen, Z., Li, Y., Mulichak, A.M., Lewis, S.D., and Shafer, J.A., in 1995 in a paper entitled "Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), and HIRUGEN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L ALPHA-THROMBIN (SMALL SUBUNIT) P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
H ALPHA-THROMBIN (LARGE SUBUNIT) P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 96%
I HIRUGEN P01050 (55-64) (HIRV1_HIRME)search Hirudo medicinalissearch 97% 13 76%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00734 (328 - 363) ALPHA-THROMBIN (SMALL SUBUNIT) Homo sapiens
P01050 (55 - 64) HIRUGEN

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
H (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
I (P01050) PF00713: Hirudinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
L (P00734) serine-type endopeptidase activitysearch proteolysissearch blood coagulationsearch extracellular regionsearch
H (P00734) catalytic activitysearch serine-type endopeptidase activitysearch calcium ion bindingsearch proteolysissearch blood coagulationsearch

Chain InterPro annotation
L Thrombin light chainsearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
I