1afw Summary



The structure was published by Mathieu, M., Modis, Y., Zeelen, J.P., et al., Lamzin, V.S., Kunau, W.H., and Wierenga, R.K., in 1997 in a paper entitled "The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 3-KETOACETYL-COA THIOLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 3-KETOACETYL-COA THIOLASE P27796 (25-417) (THIK_YEAST)search Saccharomyces cerevisiae S288csearch 94% 393 100%
B 3-KETOACETYL-COA THIOLASE P27796 (25-417) (THIK_YEAST)search Saccharomyces cerevisiae S288csearch 94% 393 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27796 (25 - 417) 3-KETOACETYL-COA THIOLASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P27796) Thiolase-relatedsearch Peroxisomal Thiolase; Chain A, domain 1search PF00108: Thiolase, N-terminal domainsearch, PF02803: Thiolase, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P27796) transferase activity, transferring acyl groups other than amino-acyl groupssearch protein bindingsearch acetyl-CoA C-acyltransferase activitysearch catalytic activitysearch transferase activity, transferring acyl groupssearch mRNA bindingsearch transferase activitysearch lipid metabolic processsearch fatty acid beta-oxidationsearch metabolic processsearch fatty acid metabolic processsearch mitochondrial intermembrane spacesearch peroxisomesearch peroxisomal matrixsearch

Chain InterPro annotation
A, B Thiolasesearch Thiolase-like, subgroupsearch Thiolase-likesearch Thiolase, active sitesearch Thiolase, conserved sitesearch Thiolase, acyl-enzyme intermediate active sitesearch Thiolase, N-terminalsearch Thiolase, C-terminalsearch