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PDBe Entry: 1ae8 
HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP
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COMPLEX (SERINE PROTEASE/INHIBITOR)
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X-RAY DIFFRACTION
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Resolution: 2.0 Å, Spacegroup: C 1 2 1
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03/12/1997, deposition: 06/03/1997, last revision: 24/02/2009
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De Simone, G.; Balliano, G.; Milla, P.; Gallina, C.; Giordano, C.; Tarricone, C.; Rizzi, M.; Bolognesi, M.; Ascenzi, P.
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Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
J.MOL.BIOL. vol:269, pag:558-569 (1997) [PubMed ID 9217260 ]
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COMPLEX (SERINE PROTEASE/INHIBITOR), BLOOD COAGULATION, N-ETHOXYCARBONYL-D-PHE-PRO-ALFA-AZALYS-P-NITROPHENYLESTER, SERINE PROTEINASE INHIBITION, GLYCOSYLATED PROTEIN
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3.4.21.5 ExPASy BRENDA (L H)
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Homo sapiens(human) 9606(L H),Hirudo medicinalis(medicinal leech) 6421(I)
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Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] P00734 (L H)
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H, I, L
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| L |
ALPHA-THROMBIN (SMALL SUBUNIT) |
Protein |
P00734 (THRB_HUMAN)
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36 |
100% |
| H |
ALPHA-THROMBIN (LARGE SUBUNIT) |
Protein |
P00734 (THRB_HUMAN)
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259 |
97% |
| I |
HIRUGEN |
Protein |
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10 |
100% |
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| H |
SUGAR (N-ACETYL-D-GLUCOSAMINE) |
NAG
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| H |
1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE |
AZL
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