› 1ae7

X-ray diffraction
2Å resolution

NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2

Released:
DOI: 10.2210/pdb1ae7/pdb
PDB entry 1ae7 coloured by chain, front view.
PDB entry 1ae7 coloured by chain, side view.
PDB entry 1ae7 coloured by chain, top view.
Source organism: Notechis scutatus scutatus
Primary publication:
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution.
Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H
FEBS Lett 301 159-64 (1992)
PMID: 1568473

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-132754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 notexin Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.61 KDa
Source organism: Notechis scutatus scutatus
UniProt:
  • Canonical: P00608 (Residues: 1-119; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P3121
Unit cell:
a: 74.6Å b: 74.6Å c: 49Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.192 not available

Quick links

Citations

7 review citations

Neurotoxins affecting neuroexocytosis.
Schiavo et al. (2000)
6 more

4 mentions without citation

Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels.
AlShammari et al. (2023)
3 more