1aby Summary

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CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)

The structure was published by Kroeger, K.S. and Kundrot, C.E., in 1997 in a paper entitled "Structures of a hemoglobin-based blood substitute: insights into the function of allosteric proteins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 283 100%
B HEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (1 - 142) HEMOGLOBIN Homo sapiens
P68871 (3 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch cytosolsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch blood microparticlesearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch
B, D (P68871) iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch hemoglobin bindingsearch extracellular regionsearch cytosolsearch blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch protein heterooligomerizationsearch oxygen transportsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch regulation of blood vessel sizesearch transportsearch renal absorptionsearch bicarbonate transportsearch response to hydrogen peroxidesearch nitric oxide transportsearch platelet aggregationsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch