› 1ab2

Solution NMR

THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL

Released:
DOI: 10.2210/pdb1ab2/pdb
PDB entry 1ab2 coloured by chain, ensemble of 20 models, front view.
PDB entry 1ab2 coloured by chain, ensemble of 20 models, side view.
PDB entry 1ab2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional solution structure of the src homology 2 domain of c-abl.
Overduin M, Rios CB, Mayer BJ, Baltimore D, Cowburn D
Cell 70 697-704 (1992)
PMID: 1505033

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00519 (Residues: 120-220; Coverage: 9%)
Gene names: ABL, ABL1, JTK7
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

26 review citations

SH2 and SH3 domains: from structure to function.
Pawson et al. (1992)
25 more

7 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
6 more