1aap Summary

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X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR

The structure was published by Hynes, T.R., Randal, M., Kennedy, L.A., Eigenbrot, C., and Kossiakoff, A.A., in 1990 in a paper entitled "X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1990.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN P05067 (287-344) (A4_HUMAN)search Homo sapienssearch < 90% 58 96%
B ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN P05067 (287-344) (A4_HUMAN)search Homo sapienssearch < 90% 58 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05067 (287 - 344) ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Small Kunitz-type inhibitors & BPTI-like toxinssearch Factor Xa Inhibitorsearch Kunitz/Bovine pancreatic trypsin inhibitor domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P05067) serine-type endopeptidase inhibitor activitysearch nervous system developmentsearch

Chain InterPro annotation
A, B Proteinase inhibitor I2, Kunitz metazoasearch Proteinase inhibitor I2, Kunitz, conserved sitesearch