1a9w Summary

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HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN

The structure was published by Sutherland-Smith, A.J., Baker, H.M., Hofmann, O.M., Brittain, T., and Baker, E.N., in 1998 in a paper entitled "Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN (BETA CHAIN) P02100 (2-147) (HBE_HUMAN)search Homo sapienssearch 99% 146 99%
F HEMOGLOBIN (BETA CHAIN) P02100 (2-147) (HBE_HUMAN)search Homo sapienssearch 99% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P02100 (2 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
E, F (P02100) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular regionsearch cytosolic small ribosomal subunitsearch blood microparticlesearch response to hydrogen peroxidesearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch oxygen transportsearch transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch
E, F (P02100) oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch hemoglobin alpha bindingsearch heme bindingsearch iron ion bindingsearch hemoglobin complexsearch cytosolsearch blood microparticlesearch blood coagulationsearch transportsearch oxygen transportsearch protein heterooligomerizationsearch negative regulation of transcription from RNA polymerase II promotersearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
E, F Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch