1a9w Summary

pdbe.org/1a9w
spacer

HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN

The structure was published by Sutherland-Smith, A.J., Baker, H.M., Hofmann, O.M., Brittain, T., and Baker, E.N., in 1998 in a paper entitled "Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN (BETA CHAIN) P02100 (2-147) (HBE_HUMAN)search Homo sapienssearch 99% 146 99%
F HEMOGLOBIN (BETA CHAIN) P02100 (2-147) (HBE_HUMAN)search Homo sapienssearch 99% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P02100 (2 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
E, F (P02100) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch bicarbonate transportsearch positive regulation of cell deathsearch transportsearch
E, F (P02100) hemoglobin complexsearch blood microparticlesearch cytosolsearch oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch heme bindingsearch metal ion bindingsearch hemoglobin alpha bindingsearch oxygen transportsearch blood coagulationsearch transportsearch protein heterooligomerizationsearch negative regulation of transcription from RNA polymerase II promotersearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
E, F Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch