1a8m Summary

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TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT

The structure was published by Reed, C., Fu, Z.Q., Wu, J., et al., Harrison, R.W., Chen, M.J., and Weber, I.T., in 1997 in a paper entitled "Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TUMOR NECROSIS FACTOR ALPHA.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TUMOR NECROSIS FACTOR ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
B TUMOR NECROSIS FACTOR ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
C TUMOR NECROSIS FACTOR ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) TUMOR NECROSIS FACTOR ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C TNF-likesearch Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (P01375) tumor necrosis factor receptor bindingsearch immune responsesearch membranesearch

Chain InterPro annotation
A, B, C Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch