1a85 Summary



The structure was published by Brandstetter, H., Engh, R.A., Von Roedern, E.G., et al., Huber, R., Bode, W., and Grams, F., in 1998 in a paper entitled "Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MMP-8. This molecule has the UniProt identifier P22894 (MMP8_HUMAN)search. The sample contained 158 residues which is < 90% of the natural sequence. Out of 158 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MMP-8 P22894 (105-262) (MMP8_HUMAN)search Homo sapienssearch < 90% 158 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22894 (105 - 262) MMP-8 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Matrix metalloproteases, catalytic domainsearch Collagenase (Catalytic Domain)search Matrixinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P22894) proteolysissearch zinc ion bindingsearch metallopeptidase activitysearch metalloendopeptidase activitysearch extracellular matrixsearch

Chain InterPro annotation
A Peptidase M10, metallopeptidasesearch Peptidase, metallopeptidasesearch Peptidase M10Asearch Metallopeptidase, catalytic domainsearch Neutrophil collagenasesearch