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EBI PDBe PDBeView

PDBe Entry: 1a7t view

METALLO-BETA-LACTAMASE WITH MES
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.85 Å, R-factor: 15.1%, Spacegroup: P 1 21 1
Released 17/06/1998, deposition: 17/03/1998, last revision: 24/02/2009
Authors Fitzgerald, P.M.D.search; Wu, J.K.search; Toney, J.H.search
Primary citation Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): a crystallographic study at 1.85-A resolution.
BIOCHEMISTRYsearch vol:37, pag:6791-6800 (1998) [PubMed ID 9578564 ]search
Keywords HYDROLASE (BETA-LACTAMASE)search, METALLO BETA-LACTAMASEsearch, ZINCsearch
EC 3.5.2.6 ExPASy BRENDA search (A B)
Organism Bacteroides fragilis 817search(A B)
UniProt Beta-lactamase type II precursor (EC 3.5.2.6) (Penicillinase) (Cephalosporinase) (Imipenem-cefoxitin hydrolyzing enzyme) P25910search (A B)
Solvent A, B
Polymers
Id Name Type UniProt Residues Observed
A, B METALLO-BETA-LACTAMASE Protein P25910 (BLAB_BACFR)search
 232 97%
Heterogens
Id Name Ligands
A, B ZINC ION ZN search
A, B SODIUM ION NA search
A, B 2-(N-MORPHOLINO)-ETHANESULFONIC ACID MES search
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