1a7m Summary



The structure was published by Hinds, M.G., Maurer, T., Zhang, J.G., Nicola, N.A., and Norton, R.S., in 1998 in a paper entitled "Solution structure of leukemia inhibitory factor." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of LEUKEMIA INHIBITORY FACTOR. This molecule has the UniProt identifier P09056 (LIF_MOUSE)search. The sample contained 180 residues which is 100% of the natural sequence. Out of 180 residues 180 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LEUKEMIA INHIBITORY FACTOR P09056 (24-203) (LIF_MOUSE)search Mus musculussearch 100% 180 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09056 (24 - 203) LEUKEMIA INHIBITORY FACTOR Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P09056) Long-chain cytokinessearch Growth Hormone; Chain: A;search PF01291: LIF / OSM familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P09056) immune responsesearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of MAPK cascadesearch positive regulation of cell proliferationsearch blood vessel remodelingsearch trophoblast giant cell differentiationsearch transcription from RNA polymerase II promotersearch embryo implantationsearch negative regulation of cell proliferationsearch lung developmentsearch tyrosine phosphorylation of Stat3 proteinsearch negative regulation of ERK1 and ERK2 cascadesearch stem cell differentiationsearch positive regulation of peptidyl-tyrosine phosphorylationsearch positive regulation of tyrosine phosphorylation of Stat3 proteinsearch negative regulation of meiosissearch positive regulation of transcription from RNA polymerase II promotersearch spongiotrophoblast differentiationsearch negative regulation of hormone secretionsearch positive regulation of macrophage differentiationsearch positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch maternal process involved in female pregnancysearch decidualizationsearch positive regulation of protein localization to nucleussearch neuron developmentsearch lung vasculature developmentsearch regulation of cell differentiationsearch positive regulation of histone H3-K27 acetylationsearch positive regulation of astrocyte differentiationsearch stem cell maintenancesearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch muscle organ morphogenesissearch leukemia inhibitory factor signaling pathwaysearch lung alveolus developmentsearch lung lobe morphogenesissearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch regulation of metanephric nephron tubule epithelial cell differentiationsearch extracellular regionsearch extracellular spacesearch cytoplasmsearch cytokine activitysearch leukemia inhibitory factor receptor bindingsearch RNA polymerase II transcription factor recruiting transcription factor activitysearch receptor bindingsearch growth factor activitysearch

Chain InterPro annotation
A Leukemia inhibitory factor /oncostatinsearch Leukemia inhibitory factorsearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Leukemia inhibitory factor /oncostatin, conserved sitesearch