› 1a7c

X-ray diffraction
1.95Å resolution

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE

Released:
DOI: 10.2210/pdb1a7c/pdb
PDB entry 1a7c coloured by chain, front view.
PDB entry 1a7c coloured by chain, side view.
PDB entry 1a7c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide.
Xue Y, Björquist P, Inghardt T, Linschoten M, Musil D, Sjölin L, Deinum J
Structure 6 627-36 (1998)
PMID: 9634700

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138525 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
PENTAPEPTIDE Chains: B, C
Molecule details ›
Chains: B, C
Length: 7 amino acids
Theoretical weight: 488 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, RIP
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 63.12Å b: 83.37Å c: 101.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.21
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

8 review citations

Conformational changes and disease--serpins, prions and Alzheimer's.
Carrell et al. (1998)
7 more

10 mentions without citation

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.
Sillen et al. (2020)
9 more