1a6a Summary

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THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3

The structure was published by Ghosh, P., Amaya, M., Mellins, E., and Wiley, D.C., in 1995 in a paper entitled "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DR-1 beta chain, and HLA class II histocompatibility antigen, gamma chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (30-205) (DRA_HUMAN)search Homo sapienssearch < 90% 176 100%
B HLA class II histocompatibility antigen, DR-1 beta chain P01912 (34-220) (2B13_HUMAN)search Homo sapienssearch < 90% 187 100%
C HLA class II histocompatibility antigen, gamma chain P04233 (103-117) (HG2A_HUMAN)search Homo sapienssearch < 90% 15 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (30 - 205) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P01912 (34 - 220) HLA class II histocompatibility antigen, DR-1 beta chain Homo sapiens
P04233 (103 - 117) HLA class II histocompatibility antigen, gamma chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C CLIP, MHC2 interactingsearch

Chain ID Cellular component (GO) Biological process (GO)
A (P01903) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch
B (P01912) membranesearch MHC class II protein complexsearch immune responsesearch antigen processing and presentationsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C