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EBI PDBe PDBeView

PDBe Entry: 1a5x view

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.9 Å, R-factor: 15.5%, Free R-factor: 21.2%, Spacegroup: P 43 21 2
Released 27/05/1998, deposition: 18/02/1998, last revision: 24/02/2009
Authors Lubkowski, J.search; Yang, F.search; Alexandratos, J.search; Wlodawer, A.search
Primary citation Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
PROC.NATL.ACAD.SCI.USAsearch vol:95, pag:4831-4836 (1998) [PubMed ID 9560188 ]search
Keywords HYDROLASEsearch, ENDONUCLEASEsearch, HIV-1 INTEGRASE INHIBITORsearch
EC 2.7.7.49 ExPASy BRENDA search 2.7.7.7 ExPASy BRENDA search 3.1.26.4 ExPASy BRENDA search (A)
Organism Rous sarcoma virus (strain Schmidt-Ruppin) 11889search(A)
UniProt Pol polyprotein [Contains: Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (RT); Integrase (IN) (pp32)] O92956search (A)
Solvent A
Polymers
Id Name Type UniProt Residues Observed
A INTEGRASE Protein O92956 (POL_RSVSB)search
 158 92%
Heterogens
Id Name Ligands
A 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID Y3 search
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