1a5e Summary



The structure was published by Byeon, I.J., Li, J., Ericson, K., et al., Kim, H.J., O'Maille, P., and Tsai, M.D., in 1998 in a paper entitled "Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TUMOR SUPPRESSOR P16INK4A. This molecule has the UniProt identifier P42771 (CD2A1_HUMAN)search. The sample contained 156 residues which is 100% of the natural sequence. Out of 156 residues 156 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TUMOR SUPPRESSOR P16INK4A P42771 (1-156) (CD2A1_HUMAN)search Homo sapienssearch 100% 156 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42771 (1 - 156) TUMOR SUPPRESSOR P16INK4A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P42771) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P42771) protein bindingsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch NF-kappaB bindingsearch protein kinase bindingsearch poly(A) RNA bindingsearch negative regulation of cell proliferationsearch replicative senescencesearch positive regulation of cellular senescencesearch senescence-associated heterochromatin focus assemblysearch cell cycle arrestsearch negative regulation of transcription, DNA-templatedsearch Ras protein signal transductionsearch cell cyclesearch mitotic cell cyclesearch negative regulation of cell-matrix adhesionsearch negative regulation of cyclin-dependent protein serine/threonine kinase activitysearch negative regulation of phosphorylationsearch positive regulation of smooth muscle cell apoptotic processsearch negative regulation of NF-kappaB transcription factor activitysearch cellular senescencesearch positive regulation of macrophage apoptotic processsearch G1/S transition of mitotic cell cyclesearch negative regulation of cell growthsearch cytoplasmsearch senescence-associated heterochromatin focussearch nucleussearch cytosolsearch

Chain InterPro annotation
A Ankyrin repeatsearch Ankyrin repeat-containing domainsearch