1a52 Summary

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ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL

The structure was published by Tanenbaum, D.M., Wang, Y., Williams, S.P., and Sigler, P.B., in 1998 in a paper entitled "Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ESTROGEN RECEPTOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN RECEPTOR P03372 (297-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 93%
B ESTROGEN RECEPTOR P03372 (297-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (297 - 554) ESTROGEN RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P03372) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch