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EBI PDBe PDBeView

PDBe Entry: 1a4w view

CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE
Summary
Header COMPLEX (SERINE PROTEASE/INHIBITORS)search
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 15.5%, Spacegroup: C 1 2 1
Released 29/04/1998, deposition: 06/02/1998, last revision: 24/02/2009
Authors Matthews, J.H.search; Krishnan, R.search; Costanzo, M.J.search; Maryanoff, B.E.search; Tulinsky, A.search
Primary citation Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
BIOPHYS.J.search vol:71, pag:2830-2839 (1996) [PubMed ID 8913620 ]search
Keywords COMPLEX (SERINE PROTEASE/INHIBITORS)search, BLOOD COAGULATIONsearch
EC 3.4.21.5 ExPASy BRENDA search (L H)
Organism Homo sapiens(human) 9606search(L H)
UniProt Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] P00734search (L H)
Solvent H, I, L
Polymers
Id Name Type UniProt Residues Observed
L ALPHA-THROMBIN (SMALL SUBUNIT) Protein P00734 (THRB_HUMAN)search
 36 72%
H ALPHA-THROMBIN (LARGE SUBUNIT) Protein P00734 (THRB_HUMAN)search
 259 95%
I HIRUGEN Protein
12 75%
Heterogens
Id Name Ligands
H SODIUM ION NA search
H 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) ANS search DAR search 2EP search
H 2-KETOTHIAZOLE KTH search
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