1a4l Summary

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ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0

The structure was published by Wang, Z. and Quiocho, F.A., in 1998 in a paper entitled "Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ADENOSINE DEAMINASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ADENOSINE DEAMINASE P03958 (4-352) (ADA_MOUSE)search Mus musculussearch 99% 349 100%
B ADENOSINE DEAMINASE P03958 (4-352) (ADA_MOUSE)search Mus musculussearch 99% 349 100%
C ADENOSINE DEAMINASE P03958 (4-352) (ADA_MOUSE)search Mus musculussearch 99% 349 100%
D ADENOSINE DEAMINASE P03958 (4-352) (ADA_MOUSE)search Mus musculussearch 99% 349 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03958 (4 - 352) ADENOSINE DEAMINASE Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P03958) Adenosine/AMP deaminasesearch Metal-dependent hydrolasessearch PF00962: Adenosine/AMP deaminasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P03958) deaminase activitysearch adenosine deaminase activitysearch purine nucleoside bindingsearch hydrolase activitysearch metal ion bindingsearch zinc ion bindingsearch purine ribonucleoside monophosphate biosynthetic processsearch adenosine catabolic processsearch in utero embryonic developmentsearch germinal center B cell differentiationsearch cell adhesionsearch positive regulation of B cell proliferationsearch purine nucleotide salvagesearch negative regulation of apoptotic processsearch dATP catabolic processsearch inosine biosynthetic processsearch lung developmentsearch positive regulation of alpha-beta T cell differentiationsearch negative regulation of thymocyte apoptotic processsearch response to morphinesearch negative regulation of inflammatory responsesearch liver developmentsearch deoxyadenosine catabolic processsearch negative regulation of leukocyte migrationsearch positive regulation of calcium-mediated signalingsearch positive regulation of T cell activationsearch negative regulation of circadian sleep/wake cycle, non-REM sleepsearch negative regulation of adenosine receptor signaling pathwaysearch positive regulation of T cell receptor signaling pathwaysearch histamine secretionsearch positive regulation of T cell differentiationsearch response to vitamin Esearch response to drugsearch trophectodermal cell differentiationsearch negative regulation of penile erectionsearch placenta developmentsearch xanthine biosynthetic processsearch positive regulation of T cell differentiation in thymussearch negative regulation of mature B cell apoptotic processsearch regulation of circadian sleep/wake cycle, sleepsearch response to hydrogen peroxidesearch response to hypoxiasearch nucleotide metabolic processsearch lung alveolus developmentsearch negative regulation of mucus secretionsearch T cell activationsearch hypoxanthine salvagesearch positive regulation of germinal center formationsearch regulation of T cell differentiationsearch hypoxanthine biosynthetic processsearch positive regulation of heart ratesearch regulation of cell-cell adhesion mediated by integrinsearch embryonic digestive tract developmentsearch Peyer's patch developmentsearch agingsearch positive regulation of smooth muscle contractionsearch neuronal cell bodysearch dendrite cytoplasmsearch plasma membranesearch external side of plasma membranesearch cytoplasmsearch cell junctionsearch membranesearch cytosolsearch cytoplasmic vesiclesearch cell surfacesearch cytoplasmic membrane-bounded vesicle lumensearch extracellular spacesearch lysosomesearch

Chain InterPro annotation
A, B, C, D Adenosine/AMP deaminase domainsearch Adenosine/adenine deaminasesearch Adenosine/AMP deaminase active sitesearch Adenosine deaminasesearch