1a41 Summary



The structure was published by Cheng, C., Kussie, P., Pavletich, N., and Shuman, S., in 1998 in a paper entitled "Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of TOPOISOMERASE I. This molecule has the UniProt identifier P68698 (TOP1_VACCW)search. The sample contained 234 residues which is < 90% of the natural sequence. Out of 234 residues 208 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TOPOISOMERASE I P68698 (81-314) (TOP1_VACCW)search Vaccinia virus WRsearch < 90% 234 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P68698 (81 - 314) TOPOISOMERASE I Vaccinia virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Eukaryotic DNA topoisomerase I, catalytic coresearch Topoisomerase I; Chain A, domain 3search, Type 1-topoisomerase catalytic fragment, domain 2search Eukaryotic DNA topoisomerase I, catalytic coresearch

Chain ID Molecular function (GO) Biological process (GO)
A (P68698) DNA topoisomerase type I activitysearch DNA bindingsearch DNA topoisomerase type II (ATP-hydrolyzing) activitysearch DNA topological changesearch

Chain InterPro annotation
A DNA topoisomerase Isearch DNA breaking-rejoining enzyme, catalytic coresearch DNA topoisomerase I, catalytic core, eukaryotic-typesearch DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typesearch DNA topoisomerase I, active sitesearch DNA topoisomerase I catalytic fragment, domain 2search