› 1a3k

X-ray diffraction
2.1Å resolution

X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1a3k/pdb
PDB entry 1a3k coloured by chain, front view.
PDB entry 1a3k coloured by chain, side view.
PDB entry 1a3k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM
J Biol Chem 273 13047-52 (1998)
PMID: 9582341

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 114-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P212121
Unit cell:
a: 37.6Å b: 58.4Å c: 64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.24
Expression system: Escherichia coli

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Citations

54 review citations

IgE in allergy and asthma today.
Gould et al. (2008)
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48 mentions without citation

Structure, Function, and Evolution of Coronavirus Spike Proteins.
Li F. (2016)
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