1a22 Summary



The structure was published by Clackson, T., Ultsch, M.H., Wells, J.A., and de Vos, A.M., in 1998 in a paper entitled "Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GROWTH HORMONE and GROWTH HORMONE RECEPTOR.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GROWTH HORMONE P01241 (27-217) (SOMA_HUMAN)search Homo sapienssearch 99% 191 94%
B GROWTH HORMONE RECEPTOR P10912 (19-256) (GHR_HUMAN)search Homo sapienssearch < 90% 238 80%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01241 (27 - 217) GROWTH HORMONE Homo sapiens
P10912 (19 - 256) GROWTH HORMONE RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P01241) Long-chain cytokinessearch Growth Hormone; Chain: A;search PF00103: Somatotropin hormone familysearch
B Fibronectin type IIIsearch Immunoglobulinssearch Fibronectin type III domainsearch, Erythropoietin receptor, ligand bindingsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P01241) hormone activitysearch prolactin receptor bindingsearch growth factor activitysearch growth hormone receptor bindingsearch protein bindingsearch metal ion bindingsearch positive regulation of JAK-STAT cascadesearch response to estradiolsearch positive regulation of insulin-like growth factor receptor signaling pathwaysearch positive regulation of activation of JAK2 kinase activitysearch positive regulation of multicellular organism growthsearch positive regulation of receptor internalizationsearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch positive regulation of peptidyl-tyrosine phosphorylationsearch positive regulation of tyrosine phosphorylation of Stat3 proteinsearch bone maturationsearch glucose transportsearch positive regulation of phosphatidylinositol 3-kinase signalingsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch JAK-STAT cascadesearch growth hormone receptor signaling pathwaysearch positive regulation of MAP kinase activitysearch extracellular regionsearch extracellular spacesearch
B (P10912) cytokine receptor activitysearch membranesearch

Chain InterPro annotation
A Somatotropin hormonesearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Somatotropin hormone, conserved sitesearch
B Long hematopoietin receptor, single chain, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Growth hormone/erythropoietin receptor, ligand bindingsearch