› 1a1u

Solution NMR

SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1a1u/pdb
PDB entry 1a1u coloured by chain, front view.
PDB entry 1a1u coloured by chain, side view.
PDB entry 1a1u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.
McCoy M, Stavridi ES, Waterman JL, Wieczorek AM, Opella SJ, Halazonetis TD
EMBO J 16 6230-6 (1997)
PMID: 9321402

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, C
Molecule details ›
Chains: A, C
Length: 35 amino acids
Theoretical weight: 4.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 324-358; Coverage: 9%)
Gene names: P53, TP53
Sequence domains: P53 tetramerisation motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DG-SA
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The p53 pathway.
Prives et al. (1999)
6 more

9 mentions without citation

IDconverter and IDClight: conversion and annotation of gene and protein IDs.
Alibés et al. (2007)
8 more