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EBI PDBe PDBeView

PDBe Entry: 1a1q view

HEPATITIS C VIRUS NS3 PROTEINASE
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.4 Å, R-factor: 22.5%, Free R-factor: 32.0%, Spacegroup: H 3 2
Released 25/03/1998, deposition: 12/12/1997, last revision: 24/02/2009
Authors Love, R.A.search; Parge, H.E.search; Wickersham, J.A.search; Hostomsky, Z.search; Habuka, N.search; Moomaw, E.W.search; Adachi, T.search; Hostomska, Z.search
Primary citation The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
CELL(CAMBRIDGE,MASS.)search vol:87, pag:331-342 (1996) [PubMed ID 8861916 ]search
Keywords HYDROLASEsearch, SERINE PROTEASEsearch
EC 2.7.7.48 ExPASy BRENDA search 3.4.21.98 ExPASy BRENDA search 3.6.1.15 ExPASy BRENDA search (A B C)
Organism Hepatitis C virus 11103search(A B C)
UniProt Genome polyprotein [Contains: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (EC 3.4.22.-) (p23); Serine protease/NTPase/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.1.-) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] P26663search (A B C)
Polymers
Id Name Type UniProt Residues Observed
A, B, C NS3 PROTEINASE Protein P26663 (POLG_HCVBK)search
 189 96%
Heterogens
Id Name Ligands
A, B, C ZINC ION ZN search
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