1a16 Summary

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AMINOPEPTIDASE P FROM E. COLI WITH THE INHIBITOR PRO-LEU

The structure was published by Wilce, M.C., Bond, C.S., Dixon, N.E., et al., Guss, J.M., Lilley, P.E., and Wilce, J.A., in 1998 in a paper entitled "Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AMINOPEPTIDASE P. This molecule has the UniProt identifier P15034 (AMPP_ECOLI)search. The sample contained 440 residues which is 100% of the natural sequence. Out of 440 residues 439 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AMINOPEPTIDASE P P15034 (2-441) (AMPP_ECOLI)search Escherichia coli K-12search 100% 440 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15034 (2 - 441) AMINOPEPTIDASE P Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P15034) Creatinase/prolidase N-terminal domainsearch, Creatinase/aminopeptidasesearch Creatine Amidinohydrolase, subunit A, domain 1search, Creatinase/methionine aminopeptidase superfamilysearch PF00557: Metallopeptidase family M24search, PF05195: Aminopeptidase P, N-terminal domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P15034) cytoplasmsearch cytosolsearch metal ion bindingsearch metallopeptidase activitysearch aminopeptidase activitysearch metalloexopeptidase activitysearch manganese ion bindingsearch protein bindingsearch peptidase activitysearch hydrolase activitysearch proteolysissearch

Chain InterPro annotation
A Peptidase M24, structural domainsearch Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved sitesearch Peptidase M24, methionine aminopeptidasesearch Aminopeptidase P, N-terminalsearch Creatinase/Aminopeptidase P, N-terminalsearch Creatinase/Aminopeptidase P/Spt16, N-terminalsearch