1a08 Summary



The structure was published by Charifson, P.S., Shewchuk, L.M., Rocque, W., et al., Rodriguez, M., Sternbach, D.D., and Consler, T.G., in 1997 in a paper entitled "Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely C-SRC TYROSINE KINASE and ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-SRC TYROSINE KINASE P12931 (144-249) (SRC_HUMAN)search Homo sapienssearch 100% 107 98%
B C-SRC TYROSINE KINASE P12931 (144-249) (SRC_HUMAN)search Homo sapienssearch 100% 107 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (144 - 249) C-SRC TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P12931) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch