1a02 Summary

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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

The structure was published by Chen, L., Glover, J.N., Hogan, P.G., Rao, A., and Harrison, S.C., in 1998 in a paper entitled "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This entry contains 10 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N NUCLEAR FACTOR OF ACTIVATED T CELLS Q13469 (392-678) (NFAC2_HUMAN)search Homo sapienssearch < 90% 301 93%
F AP-1 FRAGMENT FOS P01100 (138-193) (FOS_HUMAN)search Homo sapienssearch < 90% 56 94%
J AP-1 FRAGMENT JUN P05412 (253-308) (JUN_HUMAN)search Homo sapienssearch < 90% 56 92%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13469 (392 - 678) NUCLEAR FACTOR OF ACTIVATED T CELLS Homo sapiens
P01100 (138 - 193) AP-1 FRAGMENT FOS Homo sapiens
P05412 (253 - 308) AP-1 FRAGMENT JUN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch, Rel/Dorsal transcription factors, DNA-binding domainsearch Immunoglobulin-likesearch, Immunoglobulinssearch Rel homology domain (RHD)search, IPT/TIG domainsearch
F Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch
J Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
N (Q13469) regulation of transcription, DNA-dependentsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch
F (P01100) regulation of transcription, DNA-dependentsearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch sequence-specific DNA bindingsearch nucleussearch
J (P05412) regulation of transcription, DNA-dependentsearch sequence-specific DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
N IPT domainsearch Nuclear factor of activated T cells (NFAT)search p53-like transcription factor, DNA-bindingsearch Rel homology domainsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch
F Fos transforming proteinsearch Basic-leucine zipper domainsearch
J Transcription factor Junsearch Basic-leucine zipper domainsearch Transcription factor, Skn-1-like, DNA-binding domainsearch c-Jun Transcription Factorsearch