1a02 Summary

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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Chen, L., Glover, J.N., Hogan, P.G., Rao, A., and Harrison, S.C., in 1998 in a paper entitled "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This entry contains 10 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N NUCLEAR FACTOR OF ACTIVATED T CELLS Q13469 (392-678) (NFAC2_HUMAN)search Homo sapienssearch < 90% 301 93%
F AP-1 FRAGMENT FOS P01100 (138-193) (FOS_HUMAN)search Homo sapienssearch < 90% 56 94%
J AP-1 FRAGMENT JUN P05412 (253-308) (JUN_HUMAN)search Homo sapienssearch < 90% 56 92%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13469 (392 - 678) NUCLEAR FACTOR OF ACTIVATED T CELLS Homo sapiens
P01100 (138 - 193) AP-1 FRAGMENT FOS Homo sapiens
P05412 (253 - 308) AP-1 FRAGMENT JUN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch, Rel/Dorsal transcription factors, DNA-binding domainsearch Immunoglobulin-likesearch, Immunoglobulinssearch Rel homology domain (RHD)search, IPT/TIG domainsearch
F Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch
J Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
N (Q13469) sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch
F (P01100) sequence-specific DNA bindingsearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch
J (P05412) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
N IPT domainsearch Nuclear factor of activated T cells (NFAT)search p53-like transcription factor, DNA-bindingsearch Rel homology domainsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch
F AP-1 transcription factorsearch Basic-leucine zipper domainsearch
J Transcription factor Junsearch Basic-leucine zipper domainsearch Transcription factor, Skn-1-like, DNA-binding domainsearch