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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

X-ray diffraction
2.7Å resolution
PDB entry 1a02 coloured by chain, front view.
PDB entry 1a02 coloured by chain, side view.
PDB entry 1a02 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: AP-1 transcription factor complex FOS-JUN-NFATC2 and DNA
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Multimeric state: hetero pentamer
Accessible surface area: 26405.34 Å2
Buried surface area: 9519.07 Å2
Dissociation area: 2,924.85 Å2
Dissociation energy (ΔGdiss): 17.97 kcal/mol
Dissociation entropy (TΔSdiss): 25.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113378

Macromolecules

Nuclear factor of activated T-cells, cytoplasmic 2
Chain: N
Length: 301 amino acids
Theoretical weight: 34.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13469 (Residues: 392-678; Coverage: 31%)
Gene names: NFAT1, NFATC2, NFATP
Pfam:
InterPro:
CATH:
SCOP:
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1a02, assembly 1, front view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1a02, assembly 1, side view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1a02, assembly 1, top view.
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Protein c-Fos
Chain: F
Length: 56 amino acids
Theoretical weight: 6.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01100 (Residues: 138-193; Coverage: 15%)
Gene names: FOS, G0S7
Pfam: bZIP transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain
Protein c-Fos in PDB entry 1a02, assembly 1, front view.
Protein c-Fos in PDB entry 1a02, assembly 1, side view.
Protein c-Fos in PDB entry 1a02, assembly 1, top view.
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Transcription factor Jun
Chain: J
Length: 56 amino acids
Theoretical weight: 6.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05412 (Residues: 253-308; Coverage: 17%)
Gene name: JUN
Pfam: bZIP transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain
Transcription factor Jun in PDB entry 1a02, assembly 1, front view.
Transcription factor Jun in PDB entry 1a02, assembly 1, side view.
Transcription factor Jun in PDB entry 1a02, assembly 1, top view.
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DNA chain A
Name: DNA (5'-D(*DTP*DTP*DGP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DCP*DAP*DTP*DAP*DG)-3')
Representative chains: A
Length: 20 nucleotides
Theoretical weight: 6.18 KDa
DNA (5'-D(*DTP*DTP*DGP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DCP*DAP*DTP*DAP*DG)-3') in PDB entry 1a02, assembly 1, front view.
DNA (5'-D(*DTP*DTP*DGP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DCP*DAP*DTP*DAP*DG)-3') in PDB entry 1a02, assembly 1, side view.
DNA (5'-D(*DTP*DTP*DGP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DCP*DAP*DTP*DAP*DG)-3') in PDB entry 1a02, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3')
Representative chains: B
Length: 20 nucleotides
Theoretical weight: 6.08 KDa
DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3') in PDB entry 1a02, assembly 1, front view.
DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3') in PDB entry 1a02, assembly 1, side view.
DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3') in PDB entry 1a02, assembly 1, top view.
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