1a01 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch bicarbonate transportsearch small molecule metabolic processsearch transportsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch blood microparticlesearch
B, D (P68871) iron ion bindingsearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch hemoglobin bindingsearch haptoglobin bindingsearch oxidation-reduction processsearch oxygen transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch blood coagulationsearch nitric oxide transportsearch protein heterooligomerizationsearch renal absorptionsearch small molecule metabolic processsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch regulation of blood pressuresearch transportsearch hydrogen peroxide catabolic processsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch