1a01 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch metal ion bindingsearch protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch oxygen transporter activitysearch transportsearch oxidation-reduction processsearch oxygen transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch blood microparticlesearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch membranesearch cytosolic small ribosomal subunitsearch
B, D (P68871) heme bindingsearch haptoglobin bindingsearch metal ion bindingsearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch renal absorptionsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch platelet aggregationsearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch blood coagulationsearch nitric oxide transportsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch cytosolsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch