1a01 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch oxygen transportsearch bicarbonate transportsearch transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch small molecule metabolic processsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch oxygen transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch bicarbonate transportsearch blood coagulationsearch renal absorptionsearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch protein heterooligomerizationsearch nitric oxide transportsearch regulation of blood pressuresearch positive regulation of cell deathsearch small molecule metabolic processsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch