1a01 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) cytosolsearch extracellular regionsearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch oxygen transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch positive regulation of cell deathsearch transportsearch oxidation-reduction processsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch
B, D (P68871) extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch hemoglobin complexsearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch regulation of blood pressuresearch regulation of blood vessel sizesearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch oxygen transportsearch renal absorptionsearch nitric oxide transportsearch protein heterooligomerizationsearch blood coagulationsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch oxygen transporter activitysearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch hemoglobin bindingsearch heme bindingsearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch