1a00 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch iron ion bindingsearch extracellular regionsearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch membranesearch
B, D (P68871) renal absorptionsearch bicarbonate transportsearch blood coagulationsearch oxygen transportsearch platelet aggregationsearch nitric oxide transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch small molecule metabolic processsearch transportsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxygen transporter activitysearch heme bindingsearch protein bindingsearch hemoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch