1a00 Summary

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HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT

The structure was published by Kavanaugh, J.S., Weydert, J.A., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxygen transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch small molecule metabolic processsearch transportsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular regionsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch
B, D (P68871) heme bindingsearch protein bindingsearch hemoglobin bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch positive regulation of cell deathsearch oxygen transportsearch renal absorptionsearch blood coagulationsearch nitric oxide transportsearch platelet aggregationsearch bicarbonate transportsearch regulation of blood vessel sizesearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch protein heterooligomerizationsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch