› 1z0a

X-ray diffraction
2.12Å resolution

GDP-Bound Rab2A GTPase

Released:
DOI: 10.2210/pdb1z0a/pdb
PDB entry 1z0a coloured by chain, front view.
PDB entry 1z0a coloured by chain, side view.
PDB entry 1z0a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Eathiraj S, Pan X, Ritacco C, Lambright DG
Nature 436 415-9 (2005)
PMID: 16034420

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-158179 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-2A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 174 amino acids
Theoretical weight: 19.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61019 (Residues: 2-170; Coverage: 80%)
Gene names: RAB2, RAB2A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand GDP 4 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21212
Unit cell:
a: 98.773Å b: 128.473Å c: 68.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.219 0.279
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Rab GTPases as coordinators of vesicle traffic.
Stenmark H. (2009)
28 more

7 mentions without citation

Structural mechanisms for regulation of membrane traffic by rab GTPases.
Lee et al. (2009)
6 more