› 1xti

X-ray diffraction
1.95Å resolution

Structure of Wildtype human UAP56

Released:
DOI: 10.2210/pdb1xti/pdb
PDB entry 1xti coloured by chain, front view.
PDB entry 1xti coloured by chain, side view.
PDB entry 1xti coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human ATP-dependent splicing and export factor UAP56.
Shi H, Cordin O, Minder CM, Linder P, Xu RM
Proc Natl Acad Sci U S A 101 17628-33 (2004)
PMID: 15585580

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spliceosome RNA helicase DDX39B Chain: A
Molecule details ›
Chain: A
Length: 391 amino acids
Theoretical weight: 45.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13838 (Residues: 46-428; Coverage: 90%)
Gene names: BAT1, DDX39B, UAP56
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand IPA 4 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P1
Unit cell:
a: 37.16Å b: 49.909Å c: 62.665Å
α: 95.701° β: 101.597° γ: 111.139°
R-values:
R R work R free
0.218 0.218 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

The DEAD-box protein family of RNA helicases.
Cordin et al. (2006)
20 more

13 mentions without citation

The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases.
Buey et al. (2022)
12 more