› 1xan

X-ray diffraction
2Å resolution

HUMAN GLUTATHIONE REDUCTASE IN COMPLEX WITH A XANTHENE INHIBITOR

Released:
DOI: 10.2210/pdb1xan/pdb
PDB entry 1xan coloured by chain, front view.
PDB entry 1xan coloured by chain, side view.
PDB entry 1xan coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor.
Savvides SN, Karplus PA
J Biol Chem 271 8101-7 (1996)
PMID: 8626496

Function and Biology Details

Reaction catalysed: 
2 glutathione + NADP(+) = glutathione disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione reductase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 461 amino acids
Theoretical weight: 49.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00390 (Residues: 62-522; Coverage: 88%)
Gene names: GLUR, GRD1, GSR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
1 bound ligand:
Ligand HXP 1 x HXP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 119.79Å b: 63.35Å c: 84.65Å
α: 90° β: 58.61° γ: 90°
R-values:
R R work R free
0.158 0.158 not available
Expression system: Escherichia coli

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Citations

7 review citations

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions.
Becker et al. (2004)
6 more

9 mentions without citation

Thioredoxin reductase and its inhibitors.
Saccoccia et al. (2014)
8 more