› 1x7r

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN

Released:
DOI: 10.2210/pdb1x7r/pdb
PDB entry 1x7r coloured by chain, front view.
PDB entry 1x7r coloured by chain, side view.
PDB entry 1x7r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods.
Manas ES, Xu ZB, Unwalla RJ, Somers WS
Structure 12 2197-207 (2004)
PMID: 15576033

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136925 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen receptor Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 305-549; Coverage: 41%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
steroid receptor coactivator-3 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GEN 1 x GEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 60.882Å b: 69.833Å c: 57.365Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.224 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

20 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
19 more

30 mentions without citation

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
Katzenellenbogen et al. (2018)
29 more