› 1x59

Solution NMR

Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase

Released:
DOI: 10.2210/pdb1x59/pdb
PDB entry 1x59 coloured by chain, ensemble of 20 models, front view.
PDB entry 1x59 coloured by chain, ensemble of 20 models, side view.
PDB entry 1x59 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Nameki N, Sasagawa A, Tomizawa T, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine--tRNA ligase, cytoplasmic Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P12081 (Residues: 1-60; Coverage: 12%)
Gene names: HARS, HARS1, HRS
Sequence domains: WHEP-TRS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrained molecular dynamics
Expression system: Not provided

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