› 1vjb

X-ray diffraction
3.2Å resolution

crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen

Released:
DOI: 10.2210/pdb1vjb/pdb
PDB entry 1vjb coloured by chain, front view.
PDB entry 1vjb coloured by chain, side view.
PDB entry 1vjb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.
Greschik H, Flaig R, Renaud JP, Moras D
J Biol Chem 279 33639-46 (2004)
PMID: 15161930

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 28.39 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand OHT 2 x OHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P3221
Unit cell:
a: 74.624Å b: 74.624Å c: 144.778Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.256 0.275
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Overview of nomenclature of nuclear receptors.
Germain et al. (2006)
20 more

2 mentions without citation

Identifying unexpected therapeutic targets via chemical-protein interactome.
Yang et al. (2010)
1 more