› 1ua2

X-ray diffraction
3.02Å resolution

Crystal Structure of Human CDK7

Released:
DOI: 10.2210/pdb1ua2/pdb
PDB entry 1ua2 coloured by chain, front view.
PDB entry 1ua2 coloured by chain, side view.
PDB entry 1ua2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human CDK7 and its protein recognition properties.
Lolli G, Lowe ED, Brown NR, Johnson LN
Structure 12 2067-79 (2004)
PMID: 15530371

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 346 amino acids
Theoretical weight: 39.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50613 (Residues: 1-346; Coverage: 100%)
Gene names: CAK, CAK1, CDK7, CDKN7, MO15, STK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 4 x ATP
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 65.501Å b: 191.635Å c: 75.794Å
α: 90° β: 94.4° γ: 90°
R-values:
R R work R free
0.217 0.213 0.288
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Cyclin-dependent kinase pathways as targets for cancer treatment.
Shapiro GI. (2006)
15 more

43 mentions without citation

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
Fuss et al. (2011)
42 more