› 1u7p

X-ray diffraction
1.9Å resolution

X-ray Crystal Structure of the Hypothetical Phosphotyrosine Phosphatase MDP-1 of the Haloacid Dehalogenase Superfamily

Released:
DOI: 10.2210/pdb1u7p/pdb
PDB entry 1u7p coloured by chain, front view.
PDB entry 1u7p coloured by chain, side view.
PDB entry 1u7p coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.
Peisach E, Selengut JD, Dunaway-Mariano D, Allen KN
Biochemistry 43 12770-9 (2004)
PMID: 15461449

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Magnesium-dependent phosphatase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9D967 (Residues: 1-164; Coverage: 100%)
Gene name: Mdp1
Sequence domains: Acid Phosphatase
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand WO4 2 x WO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 68.524Å b: 57.651Å c: 76.621Å
α: 90° β: 91.97° γ: 90°
R-values:
R R work R free
0.19 0.19 0.236
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structural genomics of protein phosphatases.
Almo et al. (2007)
4 more

3 mentions without citation

Catalytic scaffolds for phosphoryl group transfer.
Allen et al. (2016)
2 more