› 1u5x

X-ray diffraction
1.8Å resolution

Crystal structure of murine APRIL at pH 5.0

Released:
DOI: 10.2210/pdb1u5x/pdb
PDB entry 1u5x coloured by chain, front view.
PDB entry 1u5x coloured by chain, side view.
PDB entry 1u5x coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The crystal structure of a proliferation-inducing ligand, APRIL.
Wallweber HJ, Compaan DM, Starovasnik MA, Hymowitz SG
J Mol Biol 343 283-90 (2004)
PMID: 15451660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 13 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9D777 (Residues: 104-241; Coverage: 57%)
Gene names: April, Tnfsf13
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: I23
Unit cell:
a: 90.779Å b: 90.779Å c: 90.779Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.214 0.256
Expression system: Escherichia coli

Quick links

Citations

14 review citations

The BAFF/APRIL system in SLE pathogenesis.
Vincent et al. (2014)
13 more