› 1u5q

X-ray diffraction
2.1Å resolution

Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

Released:
DOI: 10.2210/pdb1u5q/pdb
PDB entry 1u5q coloured by chain, front view.
PDB entry 1u5q coloured by chain, side view.
PDB entry 1u5q coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.
Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ
Structure 12 1891-900 (2004)
PMID: 15458637

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-191640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TAO2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 39.91 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9JLS3 (Residues: 1-320; Coverage: 26%)
Gene names: Tao2, Taok2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P6522
Unit cell:
a: 186.22Å b: 186.22Å c: 94.506Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.223 0.269
Expression system: Spodoptera frugiperda

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Citations

6 review citations

UnPAKing the class differences among p21-activated kinases.
Eswaran et al. (2008)
5 more

1 mention without citation

The Diverse Roles of TAO Kinases in Health and Diseases.
Fang et al. (2020)