› 1twm

X-ray diffraction
2.26Å resolution

Interleukin-1 Beta Mutant F146Y

Released:
DOI: 10.2210/pdb1twm/pdb
PDB entry 1twm coloured by chain, front view.
PDB entry 1twm coloured by chain, side view.
PDB entry 1twm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and energetic consequences of mutations in a solvated hydrophobic cavity.
Adamek DH, Guerrero L, Blaber M, Caspar DL
J Mol Biol 346 307-18 (2005)
PMID: 15663946

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 beta Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01584 (Residues: 117-269; Coverage: 57%)
Gene names: IL1B, IL1F2
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43
Unit cell:
a: 54.89Å b: 54.89Å c: 77.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.19
Expression system: Escherichia coli

Quick links

Citations

19 citation in other articles

Location of biomarkers and reagents within agarose beads of a programmable bio-nano-chip.
Jokerst et al. (2011)
18 more

1 mention without citation

In silico evidence implicating novel mechanisms of Prunella vulgaris L. as a potential botanical drug against COVID-19-associated acute kidney injury.
Yang et al. (2023)