› 1tu5

X-ray diffraction
2.37Å resolution

Crystal structure of bovine plasma copper-containing amine oxidase

Released:
DOI: 10.2210/pdb1tu5/pdb
PDB entry 1tu5 coloured by chain, front view.
PDB entry 1tu5 coloured by chain, side view.
PDB entry 1tu5 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of amine oxidase from bovine serum.
Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G
J Mol Biol 346 991-1004 (2005)
PMID: 15701511

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Primary amine oxidase, liver isozyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 746 amino acids
Theoretical weight: 82.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q29437 (Residues: 17-762; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 3 x NAG
Ligand CU 2 x CU
Ligand CA 4 x CA
Ligand CL 3 x CL
1 modified residue:
Ligand TPQ 2 x TPQ

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 77.68Å b: 131.192Å c: 134.001Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.205 0.237

Quick links

Citations

8 review citations

Amine oxidases in apoptosis and cancer.
Toninello et al. (2006)
7 more

3 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
2 more