› 1tck

Solution NMR

STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS

Released:
DOI: 10.2210/pdb1tck/pdb
PDB entry 1tck coloured by chain, ensemble of 10 models, front view.
PDB entry 1tck coloured by chain, ensemble of 10 models, side view.
PDB entry 1tck coloured by chain, ensemble of 10 models, top view.
Source organism: Conus geographus
Primary publication:
Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations.
Wakamatsu K, Kohda D, Hatanaka H, Lancelin JM, Ishida Y, Oya M, Nakamura H, Inagaki F, Sato K
Biochemistry 31 12577-84 (1992)
PMID: 1335283

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin GIIIA Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.54 KDa
Source organism: Conus geographus
Expression system: Not provided
UniProt:
  • Canonical: P01523 (Residues: 52-73; Coverage: 40%)
Sequence domains: Mu-Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 3 x HYP

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

10 review citations

Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes.
McIntosh et al. (1999)
9 more

3 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
2 more