› 1sqn

X-ray diffraction
1.45Å resolution

Progesterone Receptor Ligand Binding Domain with bound Norethindrone

Released:
DOI: 10.2210/pdb1sqn/pdb
PDB entry 1sqn coloured by chain, front view.
PDB entry 1sqn coloured by chain, side view.
PDB entry 1sqn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.
Madauss KP, Deng SJ, Austin RJ, Lambert MH, McLay I, Pritchard J, Short SA, Stewart EL, Uings IJ, Williams SP
J Med Chem 47 3381-7 (2004)
PMID: 15189034

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 261 amino acids
Theoretical weight: 30.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 673-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand NDR 2 x NDR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 57.753Å b: 64.142Å c: 70.138Å
α: 90° β: 95.84° γ: 90°
R-values:
R R work R free
0.188 0.186 0.216
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Nuclear receptor structure: implications for function.
Bain et al. (2007)
4 more

23 mentions without citation

Variability in docking success rates due to dataset preparation.
Corbeil et al. (2012)
22 more