› 1s22

X-ray diffraction
1.6Å resolution

Absolute Stereochemistry of Ulapualide A

Released:
DOI: 10.2210/pdb1s22/pdb
PDB entry 1s22 coloured by chain, front view.
PDB entry 1s22 coloured by chain, side view.
PDB entry 1s22 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Absolute stereochemistry of ulapualide A.
Allingham JS, Tanaka J, Marriott G, Rayment I
Org Lett 6 597-9 (2004)
PMID: 14961632

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand ATP 1 x ATP
Ligand ULA 1 x ULA
Ligand EDO 2 x EDO
1 modified residue:
Ligand HIC 1 x HIC

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 40.8Å b: 75.2Å c: 67.5Å
α: 90° β: 100.2° γ: 90°
R-values:
R R work R free
0.153 0.152 0.179

Quick links

Citations

5 review citations

Marine natural products.
Blunt et al. (2009)
4 more

5 mentions without citation

Actin structure and function.
Dominguez et al. (2011)
4 more