› 1rs2

X-ray diffraction
2.31Å resolution

Function and Biology Details

Reactions catalysed: 
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
7,8-dihydroneopterin = 7,8-dihydromonapterin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroneopterin aldolase Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.77 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P56740 (Residues: 1-121; Coverage: 100%)
Gene name: folB
Sequence domains: Dihydroneopterin aldolase
Structure domains: GTP Cyclohydrolase I, domain 2

Ligands and Environments

1 bound ligand:
Ligand 209 1 x 209
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I422
Unit cell:
a: 60.947Å b: 60.947Å c: 123.689Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.265 0.311
Expression system: Escherichia coli

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Citations

15 review citations

A decade of fragment-based drug design: strategic advances and lessons learned.
Hajduk et al. (2007)
14 more

1 mention without citation

Telomerase transduced osteoarthritis fibroblast-like synoviocytes display a distinct gene expression profile.
Sun et al. (2009)